Extraction site preservation using an in-situ hardening alloplastic bone graft substitute.

Dr Leventis MD, Dr Fairbairn P, Dr Horowitz RA.
Compendium of Continuing Education in Dentistry.
2014 Nov-Dec;35(4 Suppl):11-3.

This case report highlights the use of an in situ hardening alloplastic bone grafting material composed of beta tri-calcium phosphate (β-TCP) granules coated with poly(lactic-co-glycolic acid; PLGA) to preserve the dimensions and architecture of the alveolar ridge after atraumatic extraction. This material provided a stable scaffold that, although left uncovered, deterred the ingrowth of unwanted soft tissue, allowing newly formed keratinized soft tissue to proliferate over the healing grafted socket and gradually cover the site. At re-entry after 4 months adequate newly-formed bone was observed, allowing for the correct positional placement of an implant. The results of this case suggest that an in situ hardening alloplastic grafting material can be successfully utilized with minimally invasive procedures to preserve the bone and the soft tissue profile of the alveolar ridge for future implant rehabilitation.


Biological Response to β-Tricalcium Phosphate/Calcium Sulfate Synthetic Graft Material: An Experimental Study.

Leventis MD, Fairbairn P, Dontas I, et al.
Implant Dent. 2014;23:37-43

Purpose: The aim of this study is to evaluate the effect of a biphasic synthetic bone graft material composed of β-Tricalcium Phosphate (β-TCP) and Calcium Sulfate (CS) in 12 New Zealand rabbits.

Materials and Methods: A circular bicortical critical-size cranial defect was created in each of 12 rabbits. The defects were grafted with β-TCP/CS. Animals were euthanized at 3 and 6 weeks. Harvested tissue specimens were evaluated histologically and histomorphometrically. Parameters associated with new bone formation and graft resorption were measured and calculated. The results were statistically analyzed using the Mann-Whitney test.

Results: Our data demonstrated the biocompatability of synthetic β-TCP/CS, as no inflammatory response was observed and no fibrosis was developed between the graft particles and the newly formed bone. Moreover, β-TCP/CS acted as an osteoconductive scaffold that allowed a significant bone regeneration and graft bio-degradation with time.

Conclusion: In this animal model, synthetic β-TCP/CS seems to be a biocompatible, osteoconductive and bio-resorbable bone graft substitute.


Socket preservation usingin situ hardening synthetic bone graft substitute.

Leventis M, Nagursky H.
Implantologie Journal 2014;4:46-51

Eine Ridge Preservation mit Knochenersatzmaterial hat sich als minimalinvasive Methode -erwiesen, die eine Kammatrophie signifikant reduzieren kann. Im folgenden Fallbericht wird beschrieben, wie ein in situ aushärtendes, synthetisches Knochenersatzmaterial in einer -Erfolg versprechenden Weise zur Ridge Preservation eingesetzt wurde. Die Eigenschaften des -Materials führten zu einer ausgeprägten Knochenregeneration, was eine Implantation nach einer viermonatigen Heilungsphase ermöglichte.

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The body wants to heal. A promising new particulate graft material: a case study.

Farbairn P, Leventis M.
EDI Journal2014;4:58-6

The notion of post-extraction bone preservation and early placement of dental implants is not new, having been mentioned in 2003. Early placement and the use of recently developed synthetic graft materials have yielded enhanced host regeneration [2]. After twelve years and over 2,000 successful grafts using exactly the same protocol in post-extraction bone preservation the authors have found consistent benefits when working in harmony with the host’s healing process. Others have also successfully used newer alloplasts. The surgical protocol involves a three-week post extraction soft-tissue healing period followed by delayed immediate implant placement with a simultaneous synthetic (alloplastic) biphasic particulate graft without a traditional membrane.
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